The SAPhIRE programme is aimed at transforming medical practice through three approaches.

Active ADR Surveillance Initiative

Working to establish a foundation for a national active ADR surveillance network by developing and testing data and text-mining algorithms of electronic medical records.

Strong Clinical Genetics Discovery Platform

Establishing a strong discovery platform to identify the molecular signatures of ADRs that have not yet been studied or validated in Asian populations. SAPhIRE will conduct clinical studies with the goal of identifying genes in local Asian populations that alter drug metabolism or distribution or response to therapy.

Molecular Diagnostic Tests to Predict ADRs

SAPhIRE will take the next step after the discovery of genetic markers of ADRs to develop clinical-grade ADR biomarker says that will allow clinicians to tailor therapeutic decisions to an individuals's risk profile